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REVIEW ARTICLES
Year : 2019  |  Volume : 2  |  Issue : 2  |  Page : 39-47

Sweating and other thermoregulatory abnormalities in Parkinson’s disease: A review


1 Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, De Crespigny Park, London, UK; Parkinson’s Foundation Centre of Excellence, King’s College Hospital, Denmark Hill, London, UK
2 Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, De Crespigny Park, London, UK; Parkinson’s Foundation Centre of Excellence, King’s College Hospital, Denmark Hill, London, UK; Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, The Netherlands, UK
3 Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, De Crespigny Park, London, UK; Parkinson’s Foundation Centre of Excellence, King’s College Hospital, Denmark Hill, London, UK; Klinik für Gerontopsychiatrie, Asklepios Klinik Nord–Ochsenzoll, Hamburg, Germany, UK
4 Division of Clinical Neurosciences, University of Turku, Turku, Finland
5 Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, De Crespigny Park, London, UK
6 Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, De Crespigny Park, London, UK; Parkinson’s Foundation Centre of Excellence, King’s College Hospital, Denmark Hill, London, UK; Department of Psychiatry, Ng Teng Fong General Hospital, 1 Jurong East Street 21, Singapore, UK

Correspondence Address:
Dr. Valentina Leta
Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, De Crespigny Park, London, SE5 8AF
UK
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/AOMD.AOMD_2_19

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Thermoregulatory abnormalities, especially sweating disorders, are very common in Parkinson’s disease (PD). The estimated prevalence of sweating abnormalities ranges from 5.5% to 12.9% in de novo, newly diagnosed patients with PD and up to 64% during later stages of the disease. The range of thermoregulatory abnormalities in PD is broad, and includes hyperhidrosis, hypohidrosis, and hypothermia. In addition, the way in which these symptoms present themselves varies between patients and they can be chronic or fluctuating, local or generalized affecting the whole body, and related to motor complications or medication. Often there is a strong link to other autonomic symptoms, yet the exact pathogenesis behind these overlapping symptoms remains largely elusive, although current evidence points toward both central and peripheral involvement. Treatment remains difficult because of the lack of understanding of pathophysiology as well as specific clinical trials needed for evidence base. In this review, we have identified 43 studies in English language assessing sweating disorders in idiopathic PD. Here, we summarize knowledge gleaned from these reports and discuss current understanding of thermoregulatory dysfunction in PD, its phenomenology, pathophysiology, and management options.


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