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CASE REPORTS
Year : 2020  |  Volume : 3  |  Issue : 2  |  Page : 112-114

Immune-mediated chorea in a patient with kappa light-chain monoclonal gammopathy


1 Department of Neurology, All India Institute of Medical Sciences, New Delhi, India
2 Department of Hematology, All India Institute of Medical Sciences, New Delhi, India
3 Department of Neuroradiology, All India Institute of Medical Sciences, New Delhi, India

Correspondence Address:
Dr. Roopa Rajan
Department of Neurology, Neurosciences Center, All India Institute of Medical Sciences, New Delhi.
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/AOMD.AOMD_13_20

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The objective of this paper was to report on a case of steroid-responsive chorea in a patient with κ light-chain monoclonal gammopathy. In addition to subacute-onset generalized chorea, evidence of peripheral neuropathy in this elderly gentleman led us to investigate for paraproteinemia. We treated the patient with intravenous steroids in view of elevated κ light-chain assay and bone marrow biopsy, suggestive of monoclonal gammopathy of undetermined significance. There was a remarkable improvement of paresthesias and chorea at 6 months follow-up with no evidence of evolution to malignancy at 1 year. Autoimmune chorea is a treatable condition if identified and treated timely.


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