Year : 2019 | Volume
: 2 | Issue : 1 | Page : 21--27
Analysis of gait in Parkinson’s disease reflecting the effect of l-DOPA
Banashree Mondal, Supriyo Choudhury, Rebecca Banerjee, Koustav Chatterjee, Sayam Ghosal, Sidharth S Anand, Hrishikesh Kumar
Department of Neurology, RGCM Research Centre, Institute of Neurosciences, Kolkata, West Bengal, India
BACKGROUND: Gait instability is one of the disabling clinical features of majority of patients suffering from Parkinson’s disease (PD). It is partially responsive to dopamine replacement therapy. Precise evaluation of distinct l-DOPA-sensitive and l-DOPA-resistant gait profiles might help in planning therapy of PD patients with gait disorder.METHOD: In this cross-sectional analytical study, we measured the gait parameters of 70 patients and 37 healthy participants using a 6.1-m long electronic walkway containing thousands of pressure sensors embedded in a carpet. The patients were evaluated in their OFF and ON phases of l-DOPA medication, and the data were compared with age- and gender-matched healthy controls.RESULTS: Except for the cadence, most gait parameters including velocity, stride length, and step length were deranged in PD patients. The mean velocity was significantly higher among healthy volunteers (99.19cm/s) compared to PD patients (73.90cm/s, P value 0.0001). However, the mean cadence was comparable between healthy and patient groups (103.29 vs. 103.39, P value 0.966). Certain temporal parameters (cadence, cycle time, and swing time) were nonresponsive to the dopaminergic therapy.CONCLUSION: On the basis of the findings, we propose that l-DOPA treatment improves most of the spatiotemporal gait parameters but cannot completely eliminate the risk of fall.
Dr. Hrishikesh Kumar
Department of Neurology and RGCM Research Centre, Institute of Neurosciences Kolkata, 185/1 AJC Bose Road, Kolkata 700017, West Bengal, India.
|How to cite this article:|
Mondal B, Choudhury S, Banerjee R, Chatterjee K, Ghosal S, Anand SS, Kumar H. Analysis of gait in Parkinson’s disease reflecting the effect of l-DOPA.Ann Mov Disord 2019;2:21-27
|How to cite this URL:|
Mondal B, Choudhury S, Banerjee R, Chatterjee K, Ghosal S, Anand SS, Kumar H. Analysis of gait in Parkinson’s disease reflecting the effect of l-DOPA. Ann Mov Disord [serial online] 2019 [cited 2020 Jul 9 ];2:21-27
Available from: http://www.aomd.in/article.asp?issn=2590-3446;year=2019;volume=2;issue=1;spage=21;epage=27;aulast=Mondal;type=0