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  Indian J Med Microbiol
 

Figure 2: Schematic diagram of the mechanism of action of bupropion (BPP). Inhibition of dopamine and norepinephrine uptake. Also, BPP is a competitive antagonist of nicotinic acetylcholine receptors in the pineal gland that causes disinhibition of the melatonin synthesis, which leads to a decrease of depression symptom severity and possible enhancement of the efficacy of other neurotransmitters. Thus, these three pathways combined are possibly responsible for the antidepressant effect of BPP

Figure 2: Schematic diagram of the mechanism of action of bupropion (BPP). Inhibition of dopamine and norepinephrine uptake. Also, BPP is a competitive antagonist of nicotinic acetylcholine receptors in the pineal gland that causes disinhibition of the melatonin synthesis, which leads to a decrease of depression symptom severity and possible enhancement of the efficacy of other neurotransmitters. Thus, these three pathways combined are possibly responsible for the antidepressant effect of BPP