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  Indian J Med Microbiol
 

Figure 2: Summary of Clustered Regularly Interspaced Short Palindromic Repeat-CRISPR-associated protein 9 (CRISPR–Cas9)-mediated gene editing in different neurological diseases. Different modifications of CRISPR–Cas9 technology were used to edit segment of genes in various neurological diseases toward resuming normalcy or to develop therapeutics. However, all editing mentioned here did not result in complete restoration of target gene/sequence (refer text for details). CRISPR = Clustered Regularly Interspaced Short Palindromic Repeat, Cas9 = CRISPR-associated protein 9, FXS = Fragile-X syndrome, 5′-UTR = 5′ untranslated region, DMD = Duchene muscular dystrophy, AD = Alzheimer’s disease, FRDA = Friedreich’s ataxia, DNA = deoxyribonucleic acid, SCA2 = Spinocerebellar ataxia type 2, SCA3 = Spinocerebellar ataxia type 3, HD = Huntington’s disease, DM1 = type-1 myotonic dystrophy

Figure 2: Summary of Clustered Regularly Interspaced Short Palindromic Repeat-CRISPR-associated protein 9 (CRISPR–Cas9)-mediated gene editing in different neurological diseases. Different modifications of CRISPR–Cas9 technology were used to edit segment of genes in various neurological diseases toward resuming normalcy or to develop therapeutics. However, all editing mentioned here did not result in complete restoration of target gene/sequence (refer text for details). CRISPR = Clustered Regularly Interspaced Short Palindromic Repeat, Cas9 = CRISPR-associated protein 9, FXS = Fragile-X syndrome, 5′-UTR = 5′ untranslated region, DMD = Duchene muscular dystrophy, AD = Alzheimer’s disease, FRDA = Friedreich’s ataxia, DNA = deoxyribonucleic acid, SCA2 = Spinocerebellar ataxia type 2, SCA3 = Spinocerebellar ataxia type 3, HD = Huntington’s disease, DM1 = type-1 myotonic dystrophy